Determinación del recurso solar sobre fachadas verticales en Castilla y León mediante métodos de interpolación

El origen de este trabajo es conocer el potencial solar de Castilla y León para poder aprovecharlo. Para ello se ha buscado una base de datos de irradiación solar de estaciones en tierra que permita obtener, con fiabilidad, mapas de irradiación en toda la región. Se han depurado los datos y, mediante interpolación con un software adecuado, se ha obtenido el mapa calculando previamente los errores cometidos con los distintos métodos de interpolación y encontrado el que presenta menores errores. Simultáneamente se ha puesto en funcionamiento una estación radiométrica en la azotea de la EPS obteniendo datos de radiación global horizontal, difusa, reflejada y directa, y vertical en las cuatro direcciones cardinales. Los datos obtenidos se han empleado para estudiar cuál de los modelos utilizados en este trabajo para pasar de radiación global en plano horizontal a radiación global en plano vertical ajusta mejor sus datos teóricos a los reales

Implementation of PV plants in Spain: a case study

The implementation process of a photovoltaic system and its connection to the national grid in Spain is examined from an economic, an administrative and a legal standpoint. In the first place, this case study describes the solar farm, and it goes on to examine the economic aspects of electricity production, its associated costs, and relevant grants and financial subsidies. Finally, problems related to the administration of the project and the issuing of permits by local and regional authorities are discussed.project BU019A08 supported by the Department of Culture and Education of the Regional Government of Castilla y León, Spai

Small hydropower plants in Spain: a case study

A small hydropower plant in Spain is studied from an energetic and economic perspective. The viability of the facility is examined using the freeware software RETScreen. Calculated and standard operational data are compared, thereby demonstrating the feasibility of the project from all points of view. The study highlights the growing interest in renewable energies.research project BU019A08 supported by the Department of Culture and Education of the Regional Government of Castilla y León, Spai

The PV potential of vertical façades: a classic approach using experimental data from Burgos, Spain

Potential photovoltaic (PV) production from vertical façades facing the four cardinal points of the compass are calculated from daily average vertical global insolation readings measured in Burgos, Spain. Ten-minute data sets are collected over forty-five months, from January 2014 to September 2017, in the experimental campaign to produce estimates of daily average insolation levels, from which the PV potential of the vertical surfaces was calculated. Given the scarcity of data on Global Vertical Insolation (GVI), the main sky-related variables were processed in four classic decomposition models (Isotropic, Circumsolar, Klucher, and Hay) to predict the insolation values. Both the experimentally measured GVI values and those calculated with the models were then compared using the statistical indicators RMSE and MBE. The results highlighted the economic viability of Building Integrated PhotoVoltaic (BIPV) facilities, even on the north-facing façades, in comparison with the horizontal facility at the same location.Regional Government of Castile and Leon (Junta de Castilla-León) (Ref. BU034U16) through the European Regional Development Fund, and from the Spanish Ministry of Economy, Industry and Competitiveness, under the I + D + i State Programme Challenges for Society (Ref. ENE-2014-54601-

Daily data of global vertical Insolation in the four cardinal orientations in Burgos, Spain

Daily data of Global, Diffuse and Beam Horizontal Insolation and Global Vertical (North, South, East and West orientations) insolation recorded in Burgos, Spain, are presented in this paper. Ten-minute irradiance data sets are collected over forty-five months in the experimental campaign to produce estimates of daily insolation levels. This data was derived in association with the article titled: “The PV Potential of Vertical Façades: a classic approach using experimental data from Burgos, Spain” (Díez-Mediavilla et al., in press) [1]. This dataset can be used to develop and test new solar radiation and daylight models and estimate the thermal load and lighting needs in buildings for the improvement of energy efficiency.Regional Government of Castilla y Leon (Junta de Castilla-León) (Ref. BU034U16) through the European Regional Development Fund, and from the Spanish Ministry of Economy, Industry and Competitiveness, under the I+D+i State Program Challenges for Society (Ref. ENE-2014–54601-R

Mathematical interpolation methods for spatial estimation of global horizontal irradiation in Castilla-León, Spain: a case study

Four spatial interpolation methods (Inverse Distance Weighted, Spline, Kriging and Natural Neighbor) and their different variations are employed to map Global Horizontal Irradiation (GHI) in Castilla-León, Spain. The work has been performed using the software ArcGis, widely used in geostatistical applications, showing the versatility of the system and its applicability to climate data. The measuring network consists of 71 ground meteorological stations that use seven complete years of half-hourly data sets, yielding annual daily averages of GHI. The interpolation results are tested against data from the four Spanish National Meteorological Agency (AEMET) stations available in the region using standard statistical indicators (RMSE, MBE, MAPE and MAE). An additional partial cross validation of the results, which excludes five stations from the measuring network, employs different criteria to verify the results of the interpolation methods applied. This work contributes to the classification of interpolation methods to obtain climatological data across large areas with a low number of irregularly distributed of measurement points and with a low topographic complexity. The Universal Kriging method with quadratic semi-variogram shows the best results taking into account the RMSE and MAE statistical indicatorsSpanish Government (Grant ENE2014-54601-R) and Junta de Castilla- León (BU034U16). One of the authors, David González Peña, thanks to Junta de Castilla-León and European Social Fund (Orden EDU/310/2015) for financial support

Characteristics and outcomes of adult patients in the PETHEMA registry with relapsed or refractory FLT3-ITD mutation-positive acute myeloid leukemia

This retrospective study investigated outcomes of 404 patients with relapsed/refractory (R/R) FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) acute myeloid leukemia (AML) enrolled in the PETHEMA registry, pre-approval of tyrosine kinase inhibitors. Most patients (63%) had received first-line intensive therapy with 3 + 7. Subsequently, patients received salvage with intensive therapy (n = 261), non-intensive therapy (n = 63) or supportive care only (n = 80). Active salvage therapy (i.e., intensive or non-intensive therapy) resulted in a complete remission (CR) or CR without hematological recovery (CRi) rate of 42%. More patients achieved a CR/CRi with intensive (48%) compared with non-intensive (19%) salvage therapy (p < 0.001). In the overall population, median overall survival (OS) was 5.5 months; 1- and 5-year OS rates were 25% and 7%. OS was significantly (p < 0.001) prolonged with intensive or non-intensive salvage therapy compared with supportive therapy, and in those achieving CR/CRi versus no responders. Of 280 evaluable patients, 61 (22%) had an allogeneic stem-cell transplant after they had achieved CR/CRi. In conclusion, in this large cohort study, salvage treatment approaches for patients with FLT3-ITD mutated R/R AML were heterogeneous. Median OS was poor with both non-intensive and intensive salvage therapy, with best long-term outcomes obtained in patients who achieved CR/CRi and subsequently underwent allogeneic stem-cell transplant.This study was supported by Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Valencia, Spain [CB16/12/00284]

Impact of FLT3–ITD Mutation Status and Its Ratio in a Cohort of 2901 Patients Undergoing Upfront Intensive Chemotherapy: A PETHEMA Registry Study

FLT3–ITD results in a poor prognosis in terms of overall survival (OS) and relapse-free survival (RFS) in acute myeloid leukemia (AML). However, the prognostic usefulness of the allelic ratio (AR) to select post-remission therapy remains controversial. Our study focuses on the prognostic impact of FLT3–ITD and its ratio in a series of 2901 adult patients treated intensively in the pre-FLT3 inhibitor era and reported in the PETHEMA registry. A total of 579 of these patients (20%) harbored FLT3–ITD mutations. In multivariate analyses, patients with an FLT3–ITD allele ratio (AR) of >0.5 showed a lower complete remission (CR rate) and OS (HR 1.47, p = 0.009), while AR > 0.8 was associated with poorer RFS (HR 2.1; p 0.5). Using the maximally selected log-rank statistics, we established an optimal cutoff of FLT3–ITD AR of 0.44 for OS, and 0.8 for RFS. We analyzed the OS and RFS according to FLT3–ITD status in all patients, and we found that the group of FLT3–ITD-positive patients with AR 0.44, allo-HSCT was superior to auto-HSCT in terms of OS and RFS. This study provides more evidence for a better characterization of patients with AML harboring FLT3–ITD mutations.This study was fundedby Instituto de Salud Carlos III (ISCIII) through the project PI19/01518 and PI19/00730 and co- funded by the European Union, the CRIS Against Cancer Foundation, grant 2018/001, and by the Instituto de Investigación Hospital 12 de Octubre (IMAS12). APeer reviewe

Daily data of global vertical insolation in the four cardinal orientations in Burgos, Spain: dataset

Regional Government of Castilla y Leon (Junta de Castilla-León) (Ref. BU034U16) through the European Regional Development Fund, and from the Spanish Ministry of Economy, Industry and Competitiveness, under the I+D+i State Program Challenges for Society (Ref. ENE-2014–54601-R